잠시만 기다려 주세요. 로딩중입니다.

Incidence and risk factors for herpes zoster after adult liver transplantation

Annals of Surgical Treatment and Research 2019년 96권 2호 p.95 ~ 99
 ( Kim Won-Tae ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery

 ( Kim Sang-Jin ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Oh Jong-Wook ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Jeong Young-Jae ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Rhu Jin-Soo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Kim Kyung-Sik ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Lee Ji-Soo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Choi Gyu-Sung ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Kim Jong-Man ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
 ( Joh Jae-Won ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery

Abstract


Purpose: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus, which occurs frequently in liver transplant recipients with impaired cellular immunity. The purpose of this study was to evaluate the incidence and risk factors for HZ after adult liver transplantation (LT).

Methods: In our institution, 993 patients underwent adult LT from January 1997 to December 2013. We retrospectively analyzed the incidence rate of HZ and risk factors for HZ after LT.

Results: Of 993 LT recipients, 101 (10.2%) were diagnosed with HZ. The incidence of HZ at 1, 3, 5, and 10 years was 6.6%, 9.1%, 10.0%, and 11.9%, respectively. Therefore, we observed that the incidence of HZ after LT was 16.3 per 1,000 person-years. Older age (≥50 years) at LT and mycophenolate mofetil (MMF) exposure were independent risk factors of HZ infection after adult LT.

Conclusion: Patients older than 50 years or with MMF exposure are considered to be at high risk for HZ. Therefore, adult liver recipients with such factors should not be given strong immunosuppression treatments.

키워드

Herpes zoster; Incidence; Liver transplantation; Risk factors
원문 및 링크아웃 정보
  
등재저널 정보