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Verification of immunosuppression in chicks caused by Cryptosporodoum baileyi infection using Brucella abortus strain 1119-3

Korean Journal of Parasitology 1998³â 36±Ç 4È£ p.281 ~ 284
ÀÌÀ籸/Jae Ku RHEE
ÀÌÀ籸/¾çÈ«Áö/¾çÈ«Áö/±èÇöö/±èÇöö/Jae Ku RHEE/Hong Ji YANG/Hong Ji YANG/Hyeon Cheol KIM/Hyeon Cheol KIM

Abstract

´ß¿ÍÆ÷ÀÚÃæ¿¡ °¨¿°µÈ ´ß¿¡¼­ ´Ù¸¥ º´¿øÃ¼ÀÇ ÀÌÂ÷ ħÀÔ¿¡ ´ëÇÑ ¸é¿ª¾ïÁ¦´ÉÀ» ÀÔÁõÇϱâ À§ÇÏ
¿© 2 ÀÏ·É SPF º´¾Æ¸®¿¡ 2¡¿106ÀÇ ´ß¿ÍÆ÷ÀÚÃæ ³­Æ÷³¶À» ÇÑ ¹ø¿¡ °æ±¸Åõ¿©ÇÑ
´ÙÀ½ 14ÀÏ ÈÄ¿¡ 1¡¿109ÀÇ Brucella abortus strain 1119-3 ºÎÀ¯¾× 0.3 ml¸¦ ±Ù
À°ÁÖ»çÇÏ¿´´Ù. ±× ´ÙÀ½ 3-6ÀÏ °£°ÝÀ¸·Î 36Àϰ£¿¡ °ÉÃÄ Ã¤Ç÷ÇÑ ÈÄ ÆòÆÇÀÀÁý¹ÝÀÀÀ¸·Î ÀÌ ¼¼±Õ
¿¡ ´ëÇÑ ¸é¿ª¹ÝÀÀÀ» °üÂûÇÏ¿´´Ù Àü¹ÝÀûÀ¸·Î °¨¿°±º°ú ºñ°¨¿°±º ¸ðµÎ 3ÀÏ ÈıîÁö´Â ÀÌ ¼¼±Õ
¿¡ ´ëÇÑ Ç÷ûÀÀÁý¹ÝÀÀÀÌ ÀüÇô ÀϾÁö ¾Ê¾ÒÀ¸³ª ±× ÈÄ Ç÷ûÀÀÁý¿ª°¡´Â ºñ°¨¿°±º¿¡ ºñÇÏ¿©
°¨¿°±ºÀÌ ÀÇÀÇÀÖ°Ô ³·¾Ò´Ù (P<0.05). ¼¼±Õ Á¢Á¾ 15ÀÏ ÈÄ °¨¿°±º°ú ºñ°¨¿°±º¿¡ À־ ÃÖ°í
¿ª°¡´Â ¸Å¿ì ÀÇÀÇÀÖ´Â Â÷À̸¦ º¸¿´´Ù (P=0.0001) ÇÑÆí, ÁøÁ¤´ëÁ¶±ºÀº Àü ½ÇÇè±â°£À» ÅëÇÏ¿©
ÀÌ ¼¼±Õ¿¡ ´ëÇÑ Ç÷ûÀÀÁý¹ÝÀÀÀ» º¸ÀÌÁö ¾Ê¾Ò´Ù. ÀÌ ¿¬±¸°á°ú ´ß¿ÍÆ÷ÀÚÃæ¿¡ °¨¿°µÈ ´ß¿¡¼­
¹Ì»ý¹°ÀÇ Ä§ÀÔ¿¡ ´ëÇÑ ¸é¿ª¹ÝÀÀÀÌ ¾ïÁ¦µÊÀ» È®ÀÎÇÏ¿´´Ù.

Humoral immune response of young chicks to Brucella abortus strain 1119-3
inoculation was monitored to verify the degree of immunosuppression caused by
infection with Cryptosporidium baileyi. Young chicks (2-day-old) were orally inoculated
each with 2¡¿106 oocysts of C. baileyi, and then injected intramuscularly
with 0.3 ml B. abortus strain 1119-3 containing 1¡¿109 living organisms on
day 14 postinoculation (PI). Serum samples were tested by plate agglutination test on
day 17 PI onwards at an interval of 3-6 days over a period of 36 days. Infected chicks
with the coccidium showed significantly lower antibody titers than those of uninfected
controls (P<0.05). These findings document that C. bcileyi infection in early life stage
may predispose chicks easily to other potential poultry diseases.

Ű¿öµå

Cryptosporidium baileyi; Brucella abortus; immunosuppressive effect; chick;
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