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High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar

Korean Journal of Parasitology 2008년 46권 3호 p.195 ~ 198
 ( Lee Hyeong-Woo ) - 질병관리본부 국립보건연구원

김동수 ( Kim Tong-Soo ) - 질병관리본부 국립보건연구원 면역병리센터
나병국 ( Na Byung-Kuk ) - 경상대학교 의과대학 기생충학교실
조신형 ( Cho Shin-Hyeong ) - 질병관리본부 국립보건연구원
 ( Moon Sung-Ung ) - 질병관리본부 국립보건연구원
 ( Kim Yeon-Joo ) - 질병관리본부 국립보건연구원
 ( Lin Khin ) - Myanmar Vector Borne Diseases Control Project Department of Health

Abstract


Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.

키워드

Plasmodium falciparum;liver stage malaria antigen;recombinant protein;antibody response;Myanmar
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