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A Case of Fatal Strongyloidiasis in a Patient with Chronic Lymphocytic Leukemia and Molecular Characterization of the Isolate

Korean Journal of Parasitology 2008년 46권 4호 p.261 ~ 263
 ( Kia Eshrat Beigom ) - Iran University of Tehran School of Public Health

 ( Mirhendi Hossein ) - Iran University of Tehran School of Public Health
 ( Nilforoushan Mohammad Reza ) - Iran University of Tehran School of Public Health
 ( Zahabiun Farzaneh ) - Iran University of Tehran School of Public Health
 ( Rahimi Hamid Reza ) - Iran Isfahan University of Medical Sciences Al-Zahra Medical Centre
 ( Talebi Ardeshir ) - Iran Isfahan University of Medical Sciences Al-Zahra Medical Centre
 ( Kazemzadeh Hamid ) - Iran Isfahan University of Medical Sciences Al-Zahra Medical Centre
 ( Meamar Ahmad Reza ) - Iran Iran University of Medical Sciences School of Medicine

Abstract


Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.

키워드

Strongyloides stercoralis;hyperinfection;chronic lymphocytic leukemia;ITS1;ribosomal DNA
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