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Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients

Korean Journal of Parasitology 2008년 46권 4호 p.293 ~ 295
 ( Karaman Ulku ) - Turkey Inonu University School of Medicine Department of Parasitology

 ( Celik Tuncay ) - Turkey Inonu University School of Medicine Department of Parasitology
 ( Kiran Tugba Raika ) - Turkey Inonu University School of Medicine
 ( Colak Cemil ) - Turkey Firat University Department of Statistics
 ( Daldal Nilgun Ulfet ) - Turkey Inonu University School of Medicine Department of Parasitology

Abstract


The aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 ± 543.8 in optical density (mean ± SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.

키워드

Toxoplasma gondii;malondialdehyde;glutathione;nitric oxide
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