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Ultrastructural Changes in Cryptosporidium parvum Oocysts by Gamma Irradiation

Korean Journal of Parasitology 2011년 49권 1호 p.25 ~ 31
 ( Joung Mi-Gyo ) - Konkuk University School of Medicine Department of Environmental and Tropical Medicine

 ( Yun Se-Jeong ) - Konkuk University School of Medicine Department of Environmental and Tropical Medicine
 ( Joung Mi-Joung ) - Konkuk University School of Medicine Department of Environmental and Tropical Medicine
박우윤 ( Park Woo-Yoon ) - Chungbuk National University College of Medicine Department of Radiation Oncology
 ( Yu Jae-Ran ) - Konkuk University School of Medicine Department of Environmental and Tropical Medicine

Abstract


Cryptosporidium parvum is known as one of the most highly resistant parasites to gamma irradiation. To morphologically have an insight on the radioresistance of this parasite, ultrastructural changes in C. parvum sporozoites were observed after gamma irradiation using various doses (1, 5, 10, and 25 kGy) following a range of post-irradiation incubation times (10 kGy for 6, 12, 24, 48, 72, and 96 hr). The ultrastructures of C. parvum oocysts changed remarkably after a 10-kGy irradiation. Nuclear membrane changes and degranulation of dense granules were observed with high doses over 10 kGy, and morphological changes in micronemes and rhoptries were observed with very high doses over 25 kGy. Oocyst walls were not affected by irradiation, whereas the internal structures of sporozoites degenerated completely 96 hr post-irradiation using a dose of 10 kGy. From this study, morphological evidence of radioresistance of C. parvum has been supplemented.

키워드

Cryptosporidium parvum; ultrastructure; gamma irradiation
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