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A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel

Korean Journal of Parasitology 2011년 49권 1호 p.73 ~ 77
 ( Kyung Sun-Young ) - Gachon University Gil Medical Center Department of Medicine

 ( Cho Yong-Kyun ) - Gachon University Gil Medical Center Department of Medicine
 ( Kim Yu-Jin ) - Gachon University Gil Medical Center Department of Medicine
 ( Park Jeong-Woong ) - Gachon University Gil Medical Center Department of Medicine
 ( Jeong Sung-Hwan ) - Gachon University Gil Medical Center Department of Medicine
 ( Lee Jae-Ik ) - Gachon University Gil Medical Center Department of Thoracic Surgery
 ( Sung Yon-Mi ) - Gachon University Gil Medical Center Department of Radiology
 ( Lee Sang-Pyo ) - Gachon University Gil Medical Center Department of Medicine

Abstract


Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.

키워드

Paragonimus; paragonimiasis; praziquantel; triclabendazole; drug allergy; desensitization
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