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광범위큰B세포림프종에 대한 키메릭항원수용체T세포 (Chimeric Antigen Receptor T-cells) 치료

Chimeric Antigen Receptor T-Cell Therapy for Diffuse Large B-Cell Lymphoma

대한내과학회지 2019년 94권 2호 p.152 ~ 158
채희정 ( Chae Hee-Jung ) - 울산대학교 의과대학 서울아산병원 종양내과

윤덕현 ( Yoon Dok-Hyun ) - 울산대학교 의과대학 서울아산병원 종양내과

Abstract


CD19 chimeric antigen receptor T-cell (CAR-T) therapy, a genetically engineered cell therapy, showed unprecedented efficacy in the treatment of relapsed or refractory diffuse large B-cell lymphoma. Two agents, axicabtagene ciloleucel and tisagenlecleucel, were approved by the Food and Drug Administration in 2017. However, CAR-T therapy is a treatment with complex logistics and high costs, as well as inherent adverse events, including cytokine-release syndrome and neurotoxicity. In addition, predictive biomarkers for efficacy and toxicity are lacking. Industry-academy cooperation is urgently required to develop CAR-T therapy that is effective, safe, and affordable for patients in Korea.

키워드

B-cell non-Hodgkin lymphoma; Lymphoma, Large B-cell, Diffuse; Chimeric antigen receptor T-cell; CAR-T and immunotherapy
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