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만성 콩팥병 환자의 혈관 석회화

Vascular Calcification in Patients with Chronic Kidney Disease

대한내과학회지 2019년 94권 2호 p.159 ~ 169
정지용 ( Jung Ji-Yong ) - 가천대학교 의과대학 길병원 신장내과

Abstract


Cardiovascular morbidity and mortality are very common in patients with chronic kidney disease, which may result in part from vascular calcification. Vascular calcification requires osteoblastic trans-differentiation of vascular smooth muscle cells through an active and highly regulated process that is morphologically and functionally similar to bone formation in a number of ways. Multiple studies have been published on this topic, but the precise mechanism of vascular calcification remains unclear. This review presents recent insights into the mechanism of vascular calcification, as well as therapies that modulate mineral metabolism.

키워드

Vascular calcification; Chronic kidney disease; Vascular smooth muscle; Trans-differentiation; Mineralization
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