잠시만 기다려 주세요. 로딩중입니다.

비호지킨림프종에서 골수흡인 검사 결과에 따른 전체 생존율의 분석

Analysis of Overall Survival According to Bone Marrow Aspiration Results in Non-Hodgkin’s Lymphoma Patients

대한내과학회지 2019년 94권 2호 p.182 ~ 190
최정윤 ( Choi Jung-Yoon ) - 고려대학교 의과대학 내과학교실 혈액종양내과

강가원 ( Kang Ka-Won ) - 고려대학교 의과대학 내과학교실 혈액종양내과
이병현 ( Lee Byung-Hyun ) - 고려대학교 의과대학 내과학교실 혈액종양내과
유은상 ( Yu Eun-Sang ) - 고려대학교 의과대학 내과학교실 혈액종양내과
김대식 ( Kim Dae-Sik ) - 고려대학교 의과대학 내과학교실 혈액종양내과
이세련 ( Lee Se-Ryeon ) - 고려대학교 의과대학 내과학교실 혈액종양내과
성화정 ( Sung Hwa-Jung ) - 고려대학교 의과대학 내과학교실 혈액종양내과
김석진 ( Kim Seok-Jin ) - 성균관대학교 의과대학 삼성서울병원 혈액종양내과
최철원 ( Choi Chul-Won ) - 고려대학교 의과대학 내과학교실 혈액종양내과
김병수 ( Kim Byung-Soo ) - 고려대학교 의과대학 내과학교실 혈액종양내과
박용 ( Park Yong ) - 고려대학교 의과대학 내과학교실 혈액종양내과

Abstract


Background/Aims: The staging work-up for patients with non-Hodgkin’s lymphoma includes bone marrow aspiration and biopsy. Consistent results of both procedures can clarify the diagnosis. However, no clear guidelines have been established regarding positive results for bone marrow aspiration alone. The aim of this study was, therefore, to analyze the overall survival (OS) for the clinical diagnoses of these patients using morphological methods.

Methods: We performed a retrospective analysis of patients who were consecutively enrolled in the Korea University Lymphoma Registry from 1991 to 2016. OS was compared according to the bone marrow group: without bone marrow involvement (BMA-/BMBx-), with positive results for aspiration and negative results for biopsy (BMA+/BMBx-), and with bone marrow involvement in biopsy (BMBx+). OS was assessed using the Kaplan-Meier method and multivariate analysis.

Results: Of 1,735 patients, 1,326 were analyzed and 409 were excluded. In the Kaplan-Meier survival analysis, OS was significantly worse for patients in the BMBx+ group compared with those in the BMA-/BMBx- group (p < 0.001). However, there was no significant difference in OS between patients in the BMA+/BMBx- group and those in other groups (vs. BMA-/BMBx-, p = 0.163; BMBx+, p = 0.292). In multivariate analysis, by adjusting survival-related variables, the BMA+/BMBx- group showed marginal significance compared to the BMA-/BMBx- group (p = 0.081), and showed significance in the subgroup of indolent non-Hodgkin’s lymphoma patients (p = 0.003).

Conclusions: This study suggested that even if there are positive results in bone marrow aspiration alone in patients with non-Hodgkin lymphoma, attention to patient characteristics, involving significance as a poor prognosis for OS, is required.

키워드

Lymphoma, Non-Hodgkin; Biopsy; Bone marrow; Survival
원문 및 링크아웃 정보
  
등재저널 정보