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Recent Advancement of the Molecular Diagnosis in Pediatric Brain Tumor

Journal of Korean Neurosurgical Society 2018년 61권 3호 p.376 ~ 385
 ( Bae Jeong-Mo ) - Seoul National University College of Medicine Seoul National University Hospital Department of Pathology

 ( Won Jae-Kyung ) - Seoul National University College of Medicine Seoul National University Hospital Department of Pathology
 ( Park Sung-Hye ) - Seoul National University College of Medicine Seoul National University Hospital Department of Pathology

Abstract

Recent discoveries of brain tumor-related genes and fast advances in genomic testing technologies have led to the era of molecular diagnosis of brain tumor. Molecular profiling of brain tumor became the significant step in the diagnosis, the prediction of prognosis and the treatment of brain tumor. Because traditional molecular testing methods have limitations in time and cost for multiple gene tests, next-generation sequencing technologies are rapidly introduced into clinical practice. Targeted sequencing panels using these technologies have been developed for brain tumors. In this article, focused on pediatric brain tumor, key discoveries of brain tumor-related genes are reviewed and cancer panels used in the molecular profiling of brain tumor are discussed.

키워드

Brain neoplasms; Pediatrics; Molecular diagnostics; High-throughput nucleotide sequencing; Next generation sequencing
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