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Malignant Brain Tumours in Children : Present and Future Perspectives

Journal of Korean Neurosurgical Society 2018년 61권 3호 p.402 ~ 406
KMID : 1001920180610030402
저자 정보 없음  - Hospital for Sick Children Arthur and Sonia Labatt Brain Tumour Research Centre

Abstract

In contrast to many of the malignant tumors that occur in the central nervous system in adults, the management, responses to therapy, and future perspectives of children with malignant lesions of the brain hold considerable promise. Within the past 5 years, remarkable progress has been made with our understanding of the basic biology of the molecular genetics of several pediatric malignant brain tumors including medulloblastoma, ependymoma, atypical teratoid rhabdoid tumour, and high grade glioma/diffuse intrinsic pontine glioma. The recent literature in pediatric neuro-oncology was reviewed, and a summary of the major findings are presented. Meaningful sub-classifications of these tumors have arisen, placing children into discrete categories of disease with requirements for targeted therapy. While the mainstay of therapy these past 30 years has been a combination of central nervous system irradiation and conventional chemotherapy, now with the advent of high resolution genetic mapping, targeted therapies have emerged, and less emphasis is being placed on craniospinal irradiation. In this article, the present and future perspective of pediatric brain malignancy are reviewed in detail. The progress that has been made offers significant hope for the future for patients with these tumours.
KeyWords

Medulloblastoma, Ependymoma, Diffuse intrinsic pontine glioma, Atypical teratoid rhabdoid tumour, Molecular genetics, Classification
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SCI(E) 학술진흥재단(KCI) KoreaMed 대한의학회 회원