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Instrumentation Failure after Partial Corpectomy with Instrumentation of a Metastatic Spine

Journal of Korean Neurosurgical Society 2018년 61권 3호 p.415 ~ 423
KMID : 1001920180610030415
저자 정보 없음  - Seoul National University Boramae Medical Center Department of Neurosurgery

저자 정보 없음  - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Neurosurgery
저자 정보 없음  - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Neurosurgery
저자 정보 없음  - Seoul National University Boramae Medical Center Department of Biostatistics
저자 정보 없음  - Seoul National University College of Medicine Department of Neurosurgery
저자 정보 없음  - Seoul National University College of Medicine Department of Neurosurgery

Abstract

Objective: To identify the perioperative factors associated with instrument failure in patients undergoing a partial corpectomy with instrumentation (PCI) for spinal metastasis.

Methods: We assessed the one hundred twenty-four patients with who underwent PCI for a metastatic spine from 1987 to 2011. Outcome measure was the risk factor related to implantation failure. The preoperative factors analyzed were age, sex, ambulation, American Spinal Injury Association grade, bone mineral density, use of steroid, primary tumor site, number of vertebrae with metastasis, extra-bone metastasis, preoperative adjuvant chemotherapy, and preoperative spinal radiotherapy. The intraoperative factors were the number of fixed vertebrae, fixation in osteolytic vertebrae, bone grafting, and type of surgical approach. The postoperative factors included postoperative adjuvant chemotherapy and spinal radiotherapy. This study was supported by the National Research Foundation grant funded by government. There were no study-specific biases related to conflicts of interest.

Results: There were 15 instrumentation failures (15/124, 12.1%). Preoperative ambulatory status and primary tumor site were not significantly related to the development of implant failure. There were no significant associations between insertion of a bone graft into the partial corpectomy site and instrumentation failure. The preoperative and operative factors analyzed were not significantly related to instrumentation failure. In univariable and multivariable analyses, postoperative spinal radiotherapy was the only significant variable related to instrumentation failure (p=0.049 and 0.050, respectively).

Conclusion: When performing PCI in patients with spinal metastasis followed by postoperative spinal radiotherapy, the surgeon may consider the possibility of instrumentation failure and find other strategies for augmentation than the use of a bone graft for fusion.
KeyWords

Spine, Metastasis, Decompression, Radiotherapy
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