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Variability of Platelet Reactivity on Antiplatelet Therapy in Neurointervention Procedure

Journal of Korean Neurosurgical Society 2019년 62권 1호 p.3 ~ 9
 ( Yi Ho-Jun ) - Hallym University College of Medicine Hangang Sacred Heart Hospital Department of Neurosurgery

 ( Hwang Gyo-Jun ) - Hallym University College of Medicine Hangang Sacred Heart Hospital Department of Neurosurgery
 ( Lee Byoung-Hun ) - Hallym University College of Medicine Hangang Sacred Heart Hospital Department of Neurosurgery

Abstract


As more intracranial aneurysms and other cerebrovascular pathologies are treated with neurointervention procedure, thromboembolic events that frequently lead to serious neurological deficit or fatal outcomes are increasing. In order to prevent the thromboembolic events, antiplatelet therapy is used in most procedures including coil embolization, stenting, and flow diversion. However, because of variable individual pharmacodynamics responses to antiplatelet drugs, especially clopidogrel, it is difficult for clinicians to select the adequate antiplatelet regimen and its optimal dose. This article reviews the neurointervention literature related to antiplatelet therapy and suggests a strategy for tailoring antiplatelet therapy in individual patients undergoing neurointervention based on the results of platelet function testing.

키워드

Aspirin; Clopidogrel; Platelet aggregation inhibitors; Platelet function tests
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