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The Effects of Balloon-Guide Catheters on Outcomes after Mechanical Thrombectomy in Acute Ischemic Strokes : A Meta-Analysis

Journal of Korean Neurosurgical Society 2019년 62권 4호 p.389 ~ 397
 ( Ahn Jun-Hyong ) - Hallym University College of Medicine Department of Neurosurgery

 ( Cho Steve S. ) - University of Pennsylvania Perelman School of Medicine
 ( Kim Sung-Eun ) - Seoul Emergency Operations Center Department of Emergency Medicine
 ( Kim Heung-Cheol ) - Hallym University College of Medicine Department of Radiology
 ( Jeon Jin-Pyeong ) - Hallym University College of Medicine Department of Neurosurgery

Abstract


Objective: Mechanical thrombectomies with balloon-guide catheters (BGC) are thought to improve successful recanalization rates and to decrease the incidence of distal emboli compared to thrombectomies without BGC. We aimed to assess the effects of BGC on the outcomes of mechanical thrombectomy in acute ischemic strokes.

Methods: Studies from PubMed, EMBASE, and the Cochrane library database from January 2010 to February 2018 were reviewed. Random effect model for meta-analysis was used. Analyses such as meta-regression and the “trim-and-fill” method were additionally carried out.

Results: A total of seven articles involving 2223 patients were analyzed. Mechanical thrombectomy with BGC was associated with higher rates of successful recanalization (odds ratio [OR], 1.632; 95% confidence interval [CI], 1.293-2.059). BGC did not significantly decrease distal emboli, both before (OR, 0.404; 95% CI, 0.108-1.505) and after correcting for bias (adjusted OR, 1.165; 95% CI, 0.310-4.382). Good outcomes were observed more frequently in the BGC group (OR, 1.886; 95% CI, 1.564-2.273). Symptomatic intracranial hemorrhage and mortality did not differ significantly with BGC use.

Conclusion: Our meta-analysis demonstrates that BGC enhance recanalization rates. However, BGC use did not decrease distal emboli after mechanical thrombectomies. This should be interpreted with caution due to possible publication bias and heterogeneity. Additional meta-analyses based on individual patient data are needed to clarify the role of BGC in mechanical thrombectomies.

키워드

Stroke; Thrombectomy; Meta-analysis
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