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KMID : 1130320180610050150
Korean Journal of Pediatrics
2018년 61권 5호 p.150 ~ p.155


Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats

 ( Kwon Hyeok-Hee ) - Chungnam National University College of Medicine Department of Medical Science

 ( Lee Taek-Wan ) - Chungnam National University School of Medicine Chungnam National University Hospital Department of Pediatrics
 ( Hong Jin-Pyo ) - Chungnam National University College of Medicine Brain Research Institute
 ( Kim Dong-Woon ) - Chungnam National University School of Medicine Department of Anatomy
 ( Kang Joon-Won ) - Chungnam National University School of Medicine Chungnam National University Hospital Department of Pediatrics

Abstract

Purpose: Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.
Methods: We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry.

Results: Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress.

Conclusion: Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.
KeyWords

Infantile spasms, Prenatal exposure delayed effects, Potassium-chloride symporters, Glutamate decarboxylase, Gamma-Aminobutyric acid
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