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KMID : 1130320180610050160
Korean Journal of Pediatrics
2018년 61권 5호 p.160 ~ p.166


Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment

 ( Seo Yu-Mi ) - Catholic University College of Medicine Department of Pediatrics

 ( Kang Hyun-Mi ) - Catholic University College of Medicine Department of Pediatrics
 ( Lee Sung-Churl ) - Catholic University College of Medicine Department of Pediatrics
 ( Yu Jae-Won ) - Chungnam National University School of Medicine Department of Pediatrics
 ( Kil Hong-Ryang ) - Chungnam National University School of Medicine Department of Pediatrics
 ( Rhim Jung-Woo ) - Catholic University College of Medicine Department of Pediatrics
 ( Han Ji-Whan ) - Catholic University College of Medicine Department of Pediatrics
 ( Lee Kyung-Yil ) - Catholic University College of Medicine Department of Pediatrics

Abstract

Purpose: This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients.

Methods: Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204).

Results: The mean fever duration was 6.6±2.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other.

Conclusion: The severity of systemic inflammation in KD was reflected in the laboratory values including CRP, neutrophil differential, albumin, and hemoglobin. Observing changes in these laboratory parameters by repeated examinations prior to the peak of inflammation in acute KD may aid in diagnosis of earlypresenting KD patients.
KeyWords

Kawasaki disease, C-reactive protein, Albumin, Hemoglobin, Coronary artery lesion
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