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Subsequent pregnancy outcomes according to the presence of acute histologic chorioamnionitis in women with spontaneous preterm delivery

Obstetrics & Gynecology Science 2020년 63권 2호 p.126 ~ 132
 ( Kim Nam-Kyeong ) - Seoul National University Bundang Hospital Department of Obstetrics and Gynecology

 ( Choi Yae-Ji ) - Seoul National University Bundang Hospital Department of Obstetrics and Gynecology
 ( Hong Su-Been ) - Seoul National University Bundang Hospital Department of Obstetrics and Gynecology
박지윤 ( Park Jee-Yoon ) - Seoul National University Bundang Hospital Department of Obstetrics and Gynecology
오경준 ( Oh Kyung-Joon ) - Seoul National University Bundang Hospital Department of Obstetrics and Gynecology
홍준석 ( Hong Joon-Seok ) - Seoul National University Bundang Hospital Department of Obstetrics and Gynecology

Abstract


Objective: To compare subsequent pregnancy outcomes according to the presence of acute histologic chorioamnionitis (HCA) in women with spontaneous preterm delivery (SPTD).

Methods: Among 1,706 women who gave birth twice or more at our institution, 138 women delivered spontaneously at preterm (<37.0 weeks). Subsequent deliveries occurred at our institution and placental biopsy results were available. The study population was categorized into 2 groups based on the presence of acute HCA at the time of SPTD: HCA group (n=52) and non-HCA group (n=86). The primary outcome measures were gestational age at delivery, birthweight, and frequency of preterm delivery in subsequent pregnancies.

Results: The median gestational age at the time of SPTD was 34.0 weeks (interquartile range [IQR], 28.9?35.3 weeks), and the frequency of acute HCA was 52/138 (38%). There were no differences in gestational age at delivery, birthweight, and frequency of preterm delivery between the HCA group and non-HCA group (median gestational age at delivery, 38.0 weeks (IQR, 36.7?38.8 weeks) in the HCA group vs. 37.9 weeks (IQR, 35.7?39.0 weeks) in the non-HCA group; frequency of preterm delivery, 14/52 (27%) in the HCA group vs. 33/86 (38%) in the non-HCA group; and median birthweight, 3.14 kg (IQR, 2.64?3.45 kg) in the HCA group vs. 2.95 kg (IQR, 2.44?3.36 kg) in the non-HCA group; P>0.1 for all.

Conclusion: The presence of acute HCA in women at prior SPTD did not significantly affect their subsequent pregnancy outcomes.

키워드

Acute histologic chorioamnionitis; Preterm delivery; Recurrent preterm delivery; Placenta; Funisitis
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