잠시만 기다려 주세요. 로딩중입니다.

The Role of MicroRNAs in Vitiligo: Regulators and Therapeutic Targets

Annals of Dermatology 2020년 32권 6호 p.441 ~ 451
Li Lili,
소속 상세정보
 ( Li Lili ) - People’s Hospital of Guangxi Zhuang Autonomous Region Department of Dermatology

Abstract


Vitiligo is an acquired skin disorder clinically characterized by the progressive appearance of white maculae due to a loss of functioning epidermal melanocytes. Studies have shown that microRNAs (miRNAs) modulate cellular differentiation, proliferation and apoptosis, including immune cell and melanocyte development and functions. The role of miRNAs in the pathogenesis of several immune-related diseases has been explored. Novel approaches to target miRNAs have recently emerged allowing modulation of miRNAs levels in diverse pathological processes, thus making them promising targets for molecular-based diagnostics and therapy. Here, we report the present status of research on miRNAs expression and functional alterations in vitiligo, in order to more fully understand the role of these molecules in vitiligo pathology.

키워드

Melanocytes; MicroRNAs; Pathogenesis; Therapeutics; Vitiligo

원문 및 링크아웃 정보

 

등재저널 정보