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Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

Archives of Pharmacal Research 2020년 43권 6호 p.593 ~ 629
Szurpnicka Anna, Kowalczuk Anna, Szterk Arkadiusz,
소속 상세정보
 ( Szurpnicka Anna ) - National Medicines Institute Department of Natural Medicinal Products and Dietary Supplements
 ( Kowalczuk Anna ) - National Medicines Institute
 ( Szterk Arkadiusz ) - National Medicines Institute Department of Spectrometric Methods

Abstract


Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro and in vivo studies on the pharmacological activity of Viscum species. Furthermore, we proposed the possible mechanisms of action of this herb, which might include many signalling pathways. Mistletoe could regulate either similar or different targets in various pathways that act on membrane receptors, enzymes, ion channels, transporter proteins and transcriptional targets. Still, pharmacological activities of mistletoe have been investigated mainly for crude extracts. It is a new field for scientists to determined which chemical compounds are responsible for the individual biological activities of mistletoe and how these activities are achieved. As a result, mistletoe might become a source of new complementary therapies supporting the treatment of many diseases.

키워드

Mistletoe; Viscum; Extracts; Bioactivities; Mechanisms; Pharmacognosy

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