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Effects of Particulate Respirator Use on Cardiopulmonary Function in Elderly Women: a Quasi-Experimental Study

Journal of Korean Medical Science 2020년 35권 10호 p.64 ~ 64
임연희, 김우성, Choi Yu-Mi, 김환철, Na Geun-Joo, 김형렬, 홍윤철,
소속 상세정보
임연희 ( Lim Youn-Hee ) - Seoul National University Medical Research Center Institute of Environmental Medicine
김우성 ( Kim Woo-Sung ) - Seoul National University College of Medicine Department of Preventive Medicine
 ( Choi Yu-Mi ) - Seoul National University College of Medicine Department of Preventive Medicine
김환철 ( Kim Hwan-Cheol ) - Inha University Hospital Department of Occupational and Environment Medicine
 ( Na Geun-Joo ) - Inha University Hospital Department of Occupational and Environment Medicine
김형렬 ( Kim Hyoung-Ryoul ) - Catholic University College of Medicine Department of Occupational and Environmental Medicine
홍윤철 ( Hong Yun-Chul ) - Seoul National University Medical Research Center Institute of Environmental Medicine

Abstract


Background: Individual particulate respirator use may offer protection against exposure to particulate matter < 2.5 μm in diameter (PM2.5). Among elderly Korean women, we explored individual particulate respirator use and cardiopulmonary function.

Methods: Recruited in Seoul, Korea, 21 elderly, non-smoking women wore particulate respirators for six consecutive days (exlcuding time spent eating, sleeping, and bathing). We measured resting blood pressure before, during, and after respirator use and recorded systolic and diastolic blood pressure, mean arterial blood pressure, pulse pressure, and lung function. We also measured 12-hour ambulatory blood pressure at the end of the 6-day long experiment and control periods. Additionally, we examined physiological stress (heart rate variability and urinary 8-hydroxy-2′-deoxyguanosine) while wearing the particulate respirators. Person- and exposure-level covariates were also considered in the model.

Results: After the 6-day period of respirator use, resting blood pressure was reduced by 5.3 mmHg for systolic blood pressure (P = 0.013), 2.9 mmHg for mean arterial blood pressure (P = 0.079), and 3.6 mmHg for pulse pressure (P = 0.024). However, particulate respirator use was associated with changes in physiological stress markers. A parasympathetic activity marker (high frequency) significantly decreased by 24.0% (P = 0.029), whereas a sympathetic activity marker (ratio of low-to-high frequency) increased by 50.3% (P = 0.045). An oxidative stress marker, 8-hydroxy-2′-deoxyguanosine, increased by 3.4 ng/mg creatinine (P = 0.021) during the experimental period compared with that during the control period. Lung function indices indicated that wearing particulate respirators was protective; however, statistical significance was not confirmed.

Conclusion: Individual particulate respirator use may prevent PM2.5-induced blood-pressure elevation among elderly Korean women. However, the effects of particulate respirator use, including physiological stress marker elevation, should also be considered.

키워드

Blood Pressure; Elderly; Experiment; Particulate Matter; Stress

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