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Therapeutic Effects of Mesenchymal Stem Cells on a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Model

Journal of Korean Medical Science 2020년 35권 15호 p.130 ~ 130
박소영 ( Park So-Young ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology

 ( Oh In-Young ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology
김정현 ( Kim Jung-Hyun ) - Armed Forces Capital Hospital Department of Internal Medicine
김효중 ( Kim Hyo-Jung ) - Inje University Haeundae Paik Hospital Department of Internal Medicine
서보미 ( Seo Bo-Mi ) - Seongnam Citizens Medical Center Department of Pulmonary, Allergy and Critical Care Medicine
권오영 ( Kwon Oh-Young ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology
송우정 ( Song Woo-Jung ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology
권혁수 ( Kwon Hyouk-Soo ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology
조유숙 ( Cho You-Sook ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology
문희범 ( Moon Hee-Bom ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology
김태범 ( Kim Tae-Bum ) - University of Ulsan College of Medicine Asan Medical Center Department of Allergy and Clinical Immunology

Abstract


Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are the most severe cutaneous drug hypersensitivity reactions, which are unpredictable adverse drug reactions. SJS/TEN is associated with significant mortality and morbidity; however, effective treatment is difficult. Mesenchymal stem cells (MSCs) are well-known for their anti-inflammatory and tissue regeneration properties. The purpose of the present study was to verify whether MSCs could be applied for the treatment of SJS/TEN. We developed an SJS/TEN mouse model using peripheral blood mononuclear cells from a lamotrigine-induced SJS patient. MSCs were injected into the model to verify the treatment effect. In SJS model mice treated with MSCs, ocular damage rarely occurred, and apoptosis rate was significantly lower. We demonstrated a therapeutic effect of MSCs on SJS/TEN, with these cells presenting a potential novel therapy for the management of this disorder.

키워드

Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis; Mesenchymal Stem Cells; Drug Hypersensitivity; Adverse Drug Reaction
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