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Prevalence and Incidence of Neuromyelitis Optica Spectrum Disorder in Korea: Population Based Study

Journal of Korean Medical Science 2020년 35권 17호 p.115 ~ 115
이혜림, Kim Jae-Young, 석진명, 홍윤호, 임남구, 신하영, 김병조, 황순영, 민주홍, 김병준,
소속 상세정보
이혜림 ( Lee Hye-Lim ) - Korea University College of Medicine Department of Neurology
 ( Kim Jae-Young ) - Samsung Advanced Institute for Health Sciences and Technology Department of Digital Healthcare
석진명 ( Seok Jin-Myoung ) - Soonchunhyang University College of Medicine Soonchunhyang University Cheonan Hospital Department of Neurology
홍윤호 ( Hong Yoon-Ho ) - Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Neurology
임남구 ( Lim Nam-Gu ) - Daejeon Health Institute of Technology Department of Medical Administration and Information
신하영 ( Shin Ha-Young ) - Yonsei University College of Medicine Department of Neurology
김병조 ( Kim Byung-Jo ) - Korea University College of Medicine Department of Neurology
황순영 ( Hwang Soon-Young ) - Korea University college of Medicine Department of Biostatistics
민주홍 ( Min Ju-Hong ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology
김병준 ( Kim Byoung-Joon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology

Abstract


Background: Although neuromyelitis optica spectrum disorder (NMOSD) is known to be a rare disease, its prevalence and incidence have not yet been studied in Korea. We performed a population-based study to examine the prevalence and incidence of NMOSD in Korea using data from the Korean National Health Insurance (NHI) claims database.

Methods: Data from 2013 to 2017 were obtained, with a washout period set as 2013 and 2014. The prevalence and incidence of NMOSD in 2016 and 2017 were calculated using population census data. Subjects were divided into 5 groups at 15-year intervals, depending on the age at which the diagnostic code was entered. The relative risk (RR) for each age group was compared with the oldest (≥ 60 years) age group.

Results: The overall prevalence was estimated to be 3.36 and 3.56 per 100,000 individuals, with an incidence of 0.41 and 0.65 per 100,000 individuals-year in 2016 and 2017, respectively. The mean age was 43.08 (standard deviation, 14.56) years, and the ratio of male to females was 1:4.7. The incidence was higher in female individuals aged between 30 and 59 years (RR, 2.8?3.05; P < 0.05).

Conclusion: Nationwide prevalence of NMOSD in Korea was 3.36 and 3.56/100,000 and its incidence was 0.41 and 0.65/100,000-year in 2016 and 2017 respectively.

키워드

Neuromyelitis Optica Spectrum Disorder; NMOSD; Prevalence; Incidence

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