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Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population

Journal of Korean Medical Science 2020년 35권 17호 p.148 ~ 148
최창균 ( Choi Chang-Kyun ) - Chonnam National University Medical School Department of Preventive Medicine

권순석 ( Kweon Sun-Seog ) - Chonnam National University Medical School Department of Preventive Medicine
조상희 ( Cho Sang-Hee ) - Chonnam National University Hwasun Hospital Department of Hematology-Oncology
김혜연 ( Kim Hye-Yeon ) - Chonnam National University Hospital Gwangju-Jeonnam Regional Cardiocerebrovascular Center
신민호 ( Shin Min-Ho ) - Chonnam National University Medical School Department of Preventive Medicine

Abstract


The association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 (ALDH2) polymorphism. Therefore, we investigated the relationship between the ALDH2 rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The ALDH2 rs671 genotype was classified as inactive ALDH2 (GG) or active ALDH2 (GA/AA). The risk of gastric cancer was higher in men with the inactive ALDH2 than in those with active ALDH2 (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09?1.39), whereas no significant association was found between ALDH2 genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99?1.02). In men, the association between ALDH2 genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive ALDH2 and high risk of gastric cancer.

키워드

Gastric Cancer; Alcohol Drinking; ALDH2
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