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Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literature

Journal of Korean Medical Science 2020년 35권 19호 p.122 ~ 122
 ( Lee Su-A ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine

이화영 ( Lee Hwa-Young ) - Jeju National University School of Medicine Department of Internal Medicine
박요한 ( Park Yo-Han ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
고은정 ( Ko Eun-Jeong ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
반태현 ( Ban Tae-Hyun ) - Catholic University College of Medicine Eunpyeong St. Mary’s Hospital Department of Internal Medicine
정병하 ( Chung Byung-Ha ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
이현순 ( Lee Hyun-Soon ) - Hankook Renal Pathology Lab.
양철우 ( Yang Chul-Woo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine

Abstract


Chaga mushrooms are widely used in folk remedies and in alternative medicine. Contrary to many beneficial effects, its adverse effect is rarely reported. We here report a case of end-stage renal disease after long-term taking Chaga mushroom. A 49-year-old Korean man with end stage renal disease (ESRD) was transferred to our hospital. Review of kidney biopsy finding was consistent with chronic tubulointerstitial nephritis with oxalate crystal deposits and drug history revealed long-term exposure to Chaga mushroom powder due to intractable atopic dermatitis. We suspected the association between Chaga mushroom and oxalate nephropathy, and measured the oxalate content of remained Chaga mushroom. The Chaga mushroom had extremely high oxalate content (14.2/100 g). Estimated daily oxalate intake of our case was 2 times for four years and 5 times for one year higher than that of usual diet. Chaga mushroom is a potential risk factor of chronic kidney disease considering high oxalate content. Nephrologist should consider oxalate nephropathy in ESRD patients exposed to Chaga mushrooms.

키워드

Chaga Mushroom; End Stage Renal Disease; Oxalate Nephropathy
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