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Seasonal Variations and Associated Factors of Gout Attacks: a Prospective Multicenter Study in Korea

Journal of Korean Medical Science 2020년 35권 20호 p.133 ~ 133
최효진, 문기원, 김현옥, 이연아, 홍승재, 정주양, 김현아, 서창희, 하유정, 김인제, 이지수, 박은경, 이성근, 서미령, 백한주, 최상태, 송정수,
소속 상세정보
최효진 ( Choi Hyo-Jin ) - Gachon University College of Medicine Gil Medical Center Department of Internal Medicine
문기원 ( Moon Ki-Won ) - Kangwon National University School of Medicine Department of Internal Medicine
김현옥 ( Kim Hyun-Ok ) - Gyeongsang National University School of Medicine Department of Internal Medicine
이연아 ( Lee Yeon-Ah ) - Kyung Hee University Hospital Department of Internal Medicine
홍승재 ( Hong Seung-Jae ) - Kyung Hee University Hospital Department of Internal Medicine
정주양 ( Jung Ju-Yang ) - Ajou University School of Medicine Department of Rheumatology
김현아 ( Kim Hyoun-Ah ) - Ajou University School of Medicine Department of Rheumatology
서창희 ( Suh Chang-Hee ) - Ajou University School of Medicine Department of Rheumatology
하유정 ( Ha You-Jung ) - Seoul National University Bundang Hospital Department of Internal Medicine
김인제 ( Kim In-Je ) - Ewha Womans University School of Medicine Department of Internal Medicine
이지수 ( Lee Ji-Soo ) - Ewha Womans University School of Medicine Department of Internal Medicine
박은경 ( Park Eun-Kyoung ) - Pusan National University School of Medicine Department of Internal Medicine
이성근 ( Lee Seung-Geun ) - Pusan National University School of Medicine Department of Internal Medicine
서미령 ( Seo Mi-Ryoung ) - Gachon University College of Medicine Gil Medical Center Department of Internal Medicine
백한주 ( Baek Han-Joo ) - Gachon University College of Medicine Gil Medical Center Department of Internal Medicine
최상태 ( Choi Sang-Tae ) - Chung-Ang University College of Medicine Department of Internal Medicine
송정수 ( Song Jung-Soo ) - Chung-Ang University College of Medicine Department of Internal Medicine

Abstract


Background: We purposed to evaluate the seasonality and associated factors of the incidence of gout attacks in Korea.

Methods: We prospectively enrolled patients with gout attacks who were treated at nine rheumatology clinics between January 2015 and July 2018 and followed them for 1-year. Demographic data, clinical and laboratory features, and meteorological data including seasonality were collected.

Results: Two hundred-five patients (men, 94.1%) were enrolled. The proportion of patients with initial gout attacks was 46.8% (n = 96). The median age, body mass index, attack duration, and serum uric acid level at enrollment were 50.0 years, 25.4, 5.0 days, and 7.4 mg/dL, respectively. Gout attacks were most common during spring (43.4%, P < 0.001) and in March (23.4%, P < 0.001). A similar pattern of seasonality was observed in the group with initial gout attacks. Alcohol was the most common provoking factor (39.0%), particularly during summer (50.0%). The median diurnal temperature change on the day of the attack was highest in the spring (9.8°C), followed by winter (9.3°C), fall (8.6°C), and summer (7.1°C) (P = 0.027). The median change in humidity between the 2 consecutive days (the day before and the day of the attack) was significantly different among the seasons (3.0%, spring; 0.3%, summer; ?0.9%, fall; ?1.2%, winter; P = 0.015). One hundred twenty-five (61%) patients completed 1-year follow-up (51% in the initial attack group). During the follow-up period, 64 gout flares developed (21 in the initial attack group). No significant seasonal variation in the follow-up flares was found.

Conclusion: In this prospective study, the most common season and month of gout attacks in Korea are spring and March, respectively. Alcohol is the most common provoking factor, particularly during summer. Diurnal temperature changes on the day of the attack and humidity changes from the day before the attack to the day of the attack are associated with gout attack in our cohort.

키워드

Gout; Season; Alcohol; Temperature; Humidity

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