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Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report

Journal of Korean Medical Science 2020년 35권 21호 p.201 ~ 201
이종목, 이상진,
소속 상세정보
이종목 ( Lee Jong-Mok ) - Kyungpook National University School of Medicine Department of Neurology
이상진 ( Lee Sang-Jin ) - Kyungpook National University School of Medicine Department of Internal Medicine

Abstract


The neurologic manifestations concerning coronavirus disease 2019 (COVID-19) are highly penetrated. Anosmia and ageusia are one of the common acute neurologic symptoms, which develop in the early stage of COVID-19. However, it is not reported that how immunosuppressive agents affect these symptoms. We report olfactory and gustatory dysfunctions in a patient with ankylosing spondylitis (AS) treated with etanercept during COVID-19. A 53-year-old female showing AS controlled with tumor necrosis factor-α inhibitor, etanercept, had been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, presenting cough and rhinorrhea. One month after diagnosis, she complained about hyposmia and hypogeusia two days before the seronegative conversion of SARS-CoV-2, which were confirmed by a neurological examination. We speculate that the etanercept may have delayed the development of olfactory and gustatory dysfunction in the patient.

키워드

Severe Acute Respiratory Syndrome Coronavirus 2; Tumor Necrosis Factor-alpha; Neurologic Manifestations

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