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Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19

Journal of Korean Medical Science 2020년 35권 22호 p.210 ~ 210
정한길 ( Jeong Han-Gil ) - Seoul National University Bundang Hospital Department of Neurology

이용희 ( Lee Yung-Hee ) - Seoul National University Bundang Hospital Department of Internal Medicine
송경호 ( Song Kyoung-Ho ) - Seoul National University Bundang Hospital Department of Internal Medicine
황인창 ( Hwang In-Chang ) - Seoul National University Bundang Hospital Department of Internal Medicine
김의석 ( Kim Eu-Suk ) - Seoul National University Bundang Hospital Department of Internal Medicine
조영재 ( Cho Young-Jae ) - Seoul National University Bundang Hospital Department of Internal Medicine

Abstract


We report a rapidly deteriorating coronavirus disease 2019 (COVID-19) patient, a-58-year-old woman, with severe acute respiratory distress syndrome and shock with hyperpyrexia up to 41.8°C, probably due to the cytokine storm syndrome. Considering extracorporeal membrane oxygenation (ECMO) as the last resort, we applied therapeutic temperature modulation for management of hyperpyrexia. The patient demonstrated rapid improvement in oxygenation and shock after achieving normothermia, and fully recovered from COVID-19 three weeks later. Therapeutic temperature modulation may have successfully offloaded the failing cardiorespiratory system from metabolic cost and hyperinflammation induced by hyperpyrexia. The therapeutic temperature modulation can safely be applied in a specific group of patients with cytokine storm syndrome and hyperpyrexia, which may reduce the number of patients requiring ECMO in the global medical resource shortage.

키워드

SARS-CoV-2; COVID-19; Fever; Therapeutic Temperature Modulation
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