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Anti-N-methyl-D-aspartate Receptor Encephalitis: a Rare Complication of Ovarian Teratoma

Journal of Korean Medical Science 2020년 35권 24호 p.207 ~ 207
이채형 ( Lee Chae-Hyeong ) - Dongguk University College of Medicine Department of Obsterics and Gynecology

김은정 ( Kim Eun-Jung ) - Dongguk University College of Medicine Department of Obsterics and Gynecology
이민희 ( Lee Min-Hee ) - Dongguk University College of Medicine Department of Obsterics and Gynecology
임가원 ( Yim Ga-Won ) - Dongguk University College of Medicine Department of Obsterics and Gynecology
김경준 ( Kim Kyeong-Joon ) - Dongguk University College of Medicine Department of Neurology
김광기 ( Kim Kwang-Ki ) - Dongguk University College of Medicine Department of Neurology
김어진 ( Kim Eo-Jin ) - Dongguk University College of Medicine Department of Pathology
노주원 ( Roh Ju-Won ) - CHA University School of Medicine CHA Ilsan Medical Center Department of Obstetrics and Gynecology

Abstract


Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a potentially life-threatening but reversible autoimmune disorder characterized by psychiatric symptoms, cognitive dysfunction, speech dysfunction, seizures, movement disorder, decreased level of consciousness, and autonomic dysfunction or central hypoventilation. It occurs predominantly in young women and approximately half of them have underlying tumors, mainly ovarian teratoma. A 24-year old woman was admitted because of fever, headache, abnormal movement and decreased mental status. Five cycles of plasmapheresis improved her neurological and mental status. Anti-NMDAR antibodies in her CSF and serum were positive, and computed tomography revealed a 1-cm sized mass suggestive of mature cystic teratoma arising from the right ovary. We promptly performed laparoscopic right ovarian cystectomy. She was discharged after 2 weeks with mild memory deficit. Prompt removal of ovarian teratoma and multidisciplinary care are particularly important for good outcome.

키워드

Anti-N-methyl-D-aspartate Receptor Encephalitis; Autoimmune Encephalitis; Ovarian Teratoma
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