Successful Pregnancy and Delivery with Intracytoplasmic Sperm Injection in HIV-Serodiscordant Couple: the First Case in Korea
( Seong Ji-Su ) - Seoul National University College of Medicine Department of Obstetrics and Gynecology
김훈 ( Kim Hoon ) - Seoul National University College of Medicine Department of Obstetrics and Gynecology
박완범 ( Park Wan-Beom ) - Seoul National University College of Medicine Department of Internal Medicine
김남중 ( Kim Nam-Joong ) - Seoul National University College of Medicine Department of Internal Medicine
오명돈 ( Oh Myoung-Don ) - Seoul National University College of Medicine Department of Internal Medicine
박성섭 ( Park Sung-Sup ) - Seoul National University College of Medicine Department of Laboratory Medicine
박중신 ( Park Joong-Shin ) - Seoul National University College of Medicine Department of Obstetrics and Gynecology
최영민 ( Choi Young-Min ) - Seoul National University College of Medicine Department of Obstetrics and Gynecology
Abstract
With highly active antiretroviral therapy, human immunodeficiency virus (HIV) infection is considered to be a manageable chronic disease. The improved prognosis increases the desire of individuals with HIV to have biological offspring. With the establishment of washing protocol, no HIV transmission has been reported among more than 11,000 assisted reproduction technology (ART) cycles. Although the Acquired Immunodeficiency Syndrome Prevention Act in Korea prevents the use of HIV-infected blood, organs, tissues and semen, we recently obtained the authentic approval from the Korea Centers for Disease Control and Prevention for the practice of ART in HIV-serodiscordant couples. We report a 32-year-old HIV-seronegative female with her husband who was HIV-1 seropositive. After semen washing was performed by means of a density gradient and the swim-up technique, HIV-1 ribonucleic acid was not detected in the semen. An aliquot of processed semen was cryopreserved before ART. None of 3 cycles of intrauterine insemination was successful. After the third frozen-thawed embryo transfer following two cycles of intracytoplasmic sperm injection, an intrauterine singleton pregnancy was identified. She gave birth to a normal healthy male baby at full term by Cesarean section. She and her baby were tested for HIV during pregnancy and after delivery and the results were negative. Semen washing may be a safe ART method for HIV-serodiscordant couples who desire to have a baby in Korea.
키워드
Human Immunodeficiency Virus; Pregnancy; Assisted Reproductive Technique; Semen Washing
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