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Anti-Allodynic Effects of Polydeoxyribonucleotide in an Animal Model of Neuropathic Pain and Complex Regional Pain Syndrome

Journal of Korean Medical Science 2020년 35권 26호 p.225 ~ 225
이성현, 유시현, 이해진, Han Dong-Gyu, 이지영, 전승환, 조은아, 박휴정,
소속 상세정보
이성현 ( Lee Sung-Hyun ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Anesthesiology and Pain Medicine
유시현 ( Yoo Sie-Hyeon ) - Soonchunhyang University College of Medicine Soonchunhyang University Cheonan Hospital Department of Anesthesiology and Pain Medicine
이해진 ( Lee Hae-JIn ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Anesthesiology and Pain Medicine
 ( Han Dong-Gyu ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Anesthesiology and Pain Medicine
이지영 ( Lee Ji-Young ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Anesthesiology and Pain Medicine
전승환 ( Jeon Seung-Hwan ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
조은아 ( Cho Eun-Ah ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Anesthesiology and Pain Medicine
박휴정 ( Park Hue-Jung ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Anesthesiology and Pain Medicine

Abstract


Background: Spinal nerve ligation (SNL) model is one of the representative models of the neuropathic pain model. Neuropathic pain in a chronic post-ischemic pain (CPIP) mimics the symptoms of complex regional pain syndrome (CRPS). The administration of polydeoxyribonucleotide (PDRN), which has regenerative and anti-inflammatory effects, has been studied and is used in clinical practice treating various diseases. However, the analgesic effect of PDRN in a neuropathic pain or CRPS model remains unknown.

Methods: PDRN (3.3, 10, and 20 mg/kg) was administered into the subcutaneous (SC) layer of the hind paws of SNL and CPIP models. Mechanical anti-allodynic effects were then investigated using the von Frey test. In the immunohistochemical examination, dorsal root ganglia (DRG) and the spinal cord were harvested and examined for the expression of glial fibrillary acidic protein (GFAP) after the 20 mg PDRN injection.

Results: Mechanical allodynia was significantly alleviated by administration of PDRN in SNL and CPIP mice at all of the time point. As the dose of PDRN increased, the effect was greater. The 20 mg PDRN injection was found to have the most effective anti-allodynic effect. The increased expression of GFAP in DRG and the spinal cord of SNL and CPIP model decreased following the administration of PDRN than vehicle.

Conclusion: SC administration of PDRN results in the attenuation of allodynia and activation of astrocytes in neuropathic pain or CRPS models. We propose that PDRN can have significant potential advantages in neuropathic pain treatment.

키워드

Polydeoxyribonucleotide; Neuropathic Pain; Complex Regional Pain Syndrome; Spinal Nerve Ligation Model; Chronic Post-ischemic Pain Model

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