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The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019

Journal of Korean Medical Science 2020년 35권 39호 p.349 ~ 349
김인철, 송진은, 이희중, 박정호, 현미리, 이지연, 김현아, 권용식, 박재석, 윤종찬, 황종민, 이철현, 조윤경, 박형섭, 윤혁준, 남창욱, 한성욱, 허승호, Eisen Howard J., 김형섭,
소속 상세정보
김인철 ( Kim In-Cheol ) - Keimyung University Dongsan Hospital Department of Internal Medicine
송진은 ( Song Jin-Eun ) - Keimyung University Dongsan Hospital Department of Internal Medicine
이희중 ( Lee Hee-Jung ) - Keimyung University Dongsan Hospital Department of Internal Medicine
박정호 ( Park Jeong-Ho ) - Keimyung University Dongsan Hospital Department of Internal Medicine
현미리 ( Hyun Mi-Ri ) - Keimyung University Dongsan Hospital Department of Internal Medicine
이지연 ( Lee Ji-Yeon ) - Keimyung University Dongsan Hospital Department of Internal Medicine
김현아 ( Kim Hyun-Ah ) - Keimyung University Dongsan Hospital Department of Internal Medicine
권용식 ( Kwon Yong-Shik ) - Keimyung University Dongsan Hospital Department of Internal Medicine
박재석 ( Park Jae-Seok ) - Keimyung University Dongsan Hospital Department of Internal Medicine
윤종찬 ( Youn Jong-Chan ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
황종민 ( Hwang Jong-Min ) - Keimyung University Dongsan Hospital Department of Internal Medicine
이철현 ( Lee Cheol-Hyun ) - Keimyung University Dongsan Hospital Department of Internal Medicine
조윤경 ( Cho Yun-Kyeong ) - Keimyung University Dongsan Hospital Department of Internal Medicine
박형섭 ( Park Hyoung-Seob ) - Keimyung University Dongsan Hospital Department of Internal Medicine
윤혁준 ( Yoon Hyuck-Jun ) - Keimyung University Dongsan Hospital Department of Internal Medicine
남창욱 ( Nam Chang-Wook ) - Keimyung University Dongsan Hospital Department of Internal Medicine
한성욱 ( Han Seong-Wook ) - Keimyung University Dongsan Hospital Department of Internal Medicine
허승호 ( Hur Seung-Ho ) - Keimyung University Dongsan Hospital Department of Internal Medicine
 ( Eisen Howard J. ) - Pennsylvania State University Milton S. Hershey Medical Center Heart and Vascular Institute
김형섭 ( Kim Hyung-Seop ) - Keimyung University Dongsan Hospital Department of Internal Medicine

Abstract


Backgrounds: The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes.

Methods: This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed.

Results: A total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P = 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P = 0.008).

Conclusion: The increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19.

키워드

Coronavirus; COVID-19, Cardiac Injury Markers; In-hospital Mortality

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