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Epidemiology of Congenital Bleeding Disorders: a Nationwide Population-based Korean Study

Journal of Korean Medical Science 2020년 35권 39호 p.350 ~ 350
윤회수, 한유진, 김영진, 김민진, 변자민, 육태미, 이재희, 박태성, 유종하,
소속 상세정보
윤회수 ( Yoon Hoi-Soo ) - Kyung Hee University School of Medicine Department of Pediatrics
한유진 ( Han Yu-Jin ) - Kyung Hee University School of Medicine Department of Laboratory Medicine
김영진 ( Kim Young-Jin ) - Kyung Hee University School of Medicine Department of Laboratory Medicine
김민진 ( Kim Min-Jin ) - Seegene Medical Foundation
변자민 ( Byun Ja-Min ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine
육태미 ( Youk Tae-Mi ) - National Health Insurance Service Ilsan Hospital Research Institute
이재희 ( Lee Jae-Hee ) - Chosun University Hospital Department of Pediatrics
박태성 ( Park Tae-Sung ) - Kyung Hee University School of Medicine Department of Laboratory Medicine
유종하 ( Yoo Jong-Ha ) - National Health Insurance Service Ilsan Hospital Department of Laboratory Medicine

Abstract


Background: Except for data in the Korea Hemophilia Foundation Registry, little is known of the epidemiology of congenital bleeding disorders in Korea.

Methods: Data were obtained from the Korean Health Insurance Review and Assessment Service (HIRA) database.

Results: From 2010 to 2015, there were 2,029 patients with congenital bleeding disorders in the Korean HIRA database: 38% (n = 775) of these patients had hemophilia A (HA), 25% (n = 517) had von Willebrand disease (vWD), 7% (n = 132) had hemophilia B (HB), and 25% (n = 513) had less common factor deficiencies. The estimated age-standardized incidence rate (ASR) of HA and HB was 1.78?3.15/100,000 and 0.31?0.51/100,000, respectively. That of vWD was 1.38?1.95/100,000. The estimated ASR of HA showed increase over time though the number of new patients did not increase. Most patients with congenital bleeding disorders were younger than 19 years old (47.8%), and most were registered in Gyeonggi (22.1%) and Seoul (19.2%).

Conclusion: This is the first nationwide population-based study of congenital bleeding disorders in Korea. This study provides data that will enable more accurate estimations of patients with vWD. This information will help advance the comprehensive care of congenital bleeding disorders. We need to continue to obtain more detailed information on patients to improve the management of these diseases.

키워드

Congenital Bleeding Disorder; Epidemiology; Korea; Nationwide

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