잠시만 기다려 주세요. 로딩중입니다.

Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): a Multicenter Cohort Study

Journal of Korean Medical Science 2020년 35권 40호 p.366 ~ 366
김민관, 남종호, 손장원, 김선오, 손낙훈, 안철민, 심지영, 홍그루, 김인철, 최진우, 강승모, 최영호, 윤혜경, 엄재선, 정인현,
소속 상세정보
김민관 ( Kim Min-Kwan ) - Yonsei University College of Medicine Yongin Severance Hospital Department of Internal Medicine
남종호 ( Nam Jong-Ho ) - Yeungnam University Medical Center Division of Cardiology
손장원 ( Son Jang-Won ) - Yeungnam University Medical Center Division of Cardiology
김선오 ( Kim Sun-Oh ) - Yeungnam University Medical Center Department of Internal Medicine
손낙훈 ( Son Nak-Hoon ) - Yonsei University College of Medicine Yongin Severance Hospital Center for Digital Health
안철민 ( Ahn Chul-Min ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
심지영 ( Shim Chi-Young ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
홍그루 ( Hong Geu-Ru ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
김인철 ( Kim In-Cheol ) - Keimyung University School of Medicine Keimyung University Dongsan Hospital Department of Internal Medicine
최진우 ( Choi Jin-Woo ) - Chungju Medical Center
강승모 ( Kang Seung-Mo ) - Chungju Medical Center
최영호 ( Choi Yeoung-Ho ) - Chungju Medical Center
윤혜경 ( Yoon Hae-Kyoung ) - Chungju Medical Center
엄재선 ( Uhm Jae-Sun ) - Yonsei University College of Medicine Yongin Severance Hospital Department of Internal Medicine
정인현 ( Jung In-Hyun ) - Yonsei University College of Medicine Yongin Severance Hospital Department of Internal Medicine

Abstract


Background: This study aimed to investigate the cardiac manifestations of coronavirus disease 2019 (COVID-19).

Methods: From February to March 2020, we prospectively and retrospectively enrolled consecutive patients diagnosed with COVID-19. Patient's data such as the demographic characteristics, symptoms, vital signs, laboratory and radiologic findings, electrocardiographic, and echocardiographic data, including the global longitudinal strain (GLS) of both ventricles, were obtained.

Results: Forty patients (median age, 58 years; 50% men) were enrolled in the initial analysis. Patients were classified into severe and nonsevere groups based on the current guidelines. The 13 patients in the severe group were significantly older, had a greater prevalence of bilateral pneumonia and leukocytosis, and higher aspartate transaminase levels than patients in the nonsevere group. Patients in the severe group had a slightly lower left ventricular ejection fraction (LVEF) than those in the nonsevere group (median [interquartile range], 61.0% [58.5%, 62.3%] vs. 66.7% [60.6%, 69.8%], P = 0.015). In a subgroup of 34 patients in whom GLS could be analyzed, patients in the severe group had a significantly impaired left ventricular GLS (LVGLS) than those in the nonsevere group (?18.1% [?18.8%, ?17.1%] vs. ?21.7% [?22.9%, ?19.9%], P = 0.001). There were no significant differences in total wall (RVGLStotal, ?19.3% [?23.9%, ?18.4%] vs. ?24.3% [?26.0%, ?22.6%], P = 0.060) and free wall (RVGLSfw, ?22.7% [?27.2%, ?18.6%] vs. ?28.8% [?30.4%, ?24.1%], P = 0.066) right ventricle GLS (RVGLS).

Conclusion: Patients with severe COVID-19 had lower LVEF and LVGLS. RVGLS was not different between patients with severe and nonsevere COVID-19.

키워드

Coronavirus; COVID-19; Echocardiography; Global Longitudinal Strain; Ejection Fraction; Disease Severity

원문 및 링크아웃 정보

 

등재저널 정보