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Trend of Olfactory and Gustatory Dysfunction in COVID-19 Patients in a Quarantine Facility

Journal of Korean Medical Science 2020년 35권 41호 p.375 ~ 375
서민영, 석혜리, 황선진, 최희경, Jeon Ji-Hoon, 손장욱, 박대원, 이승훈, 최원석,
소속 상세정보
서민영 ( Seo Min-Young ) - Korea University College of Medicine Korea University Ansan Hospital Department of Otorhinolaryngology-Head and Neck Surgery
석혜리 ( Seok Hye-Ri ) - Korea University College of Medicine Korea University Ansan Hospital Department of Internal Medicine
황선진 ( Hwang Sun-Jin ) - Korea University College of Medicine Korea University Ansan Hospital Department of Otorhinolaryngology-Head and Neck Surgery
최희경 ( Choi Hee-Kyoung ) - Korea University College of Medicine Korea University Ansan Hospital Department of Internal Medicine
 ( Jeon Ji-Hoon ) - Korea University College of Medicine Korea University Ansan Hospital Department of Internal Medicine
손장욱 ( Sohn Jang-Wook ) - Korea University College of Medicine Korea University Anam Hospital Department of Internal Medicine
박대원 ( Park Dae-Won ) - Korea University College of Medicine Korea University Ansan Hospital Department of Internal Medicine
이승훈 ( Lee Seung-Hoon ) - Korea University College of Medicine Korea University Ansan Hospital Department of Otorhinolaryngology-Head and Neck Surgery
최원석 ( Choi Won-Suk ) - Korea University College of Medicine Korea University Ansan Hospital Department of Internal Medicine

Abstract


Background: Olfactory and gustatory dysfunction has been reported as characteristic symptoms of coronavirus disease 2019 (COVID-19). This study evaluated olfactory and gustatory dysfunction in mild COVID-19 patients using validated assessment methods.

Methods: A prospective surveillance study was conducted for mild COVID-19 patients who were isolated at the Gyeonggi International Living and Treatment Support Center (LTSC), Korea. Olfactory function was assessed using the Korean version of the Questionnaire of Olfactory Disorders (QOD) and Cross-Cultural Smell Identification Test (CC-SIT). Gustatory function was assessed using an 11-point Likert scale and 6-n-propylthiouracil, phenylthiocarbamide, and control strips. All patients underwent nasal and oral cavity endoscopic examination.

Results: Of the 62 patients at the LTSC, 15 patients (24.2%) complained of olfactory or gustatory dysfunction on admission. Four of 10 patients who underwent functional evaluation did not have general symptoms and 2 were asymptomatic. The mean short version of QOD-negative statements and QOD-visual analogue scale scores were 13 ± 6 and 4.7 ± 3.6, respectively. The mean CC-SIT score was 8 ± 2. No patients showed anatomical abnormalities associated with olfactory dysfunction on endoscopic examination. The mean Likert scale score for function was 8 ± 2, and there were no abnormal lesions in the oral cavity of any patient.

Conclusions: The prevalence of olfactory and gustatory dysfunction was 24.2% in mild COVID-19 patients. All patients had hyposmia due to sensorineural olfactory dysfunction, which was confirmed using validated olfactory and gustatory evaluation methods and endoscopic examination. Olfactory and gustatory dysfunction may be characteristic indicators of mild COVID-19.

키워드

COVID-19; SARS-CoV-2; Olfaction Disorders; Taste Disorders

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