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Effect of Prostaglandin Analogues on Central Corneal Thickness: 3-Year Follow-up Results

Korean Journal of Ophthalmology 2020년 34권 5호 p.347 ~ 352
장민수, 강경은, 조병주,
소속 상세정보
장민수 ( Jang Min-Su ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Ophthalmology
강경은 ( Kang Kyung-Eun ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Ophthalmology
조병주 ( Cho Byung-Joo ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Ophthalmology

Abstract


Purpose: To evaluate the effects of each subgroup of prostaglandin analogues (PGAs) on central corneal thickness (CCT) in patients with normal tension glaucoma (NTG).

Methods: We retrospectively reviewed 55 eyes of 55 patients with NTG who were receiving PGA therapy. Patients who were treated with 0.005% latanoprost (16 eyes), 0.0015% tafluprost (16 eyes), or 0.004% travoprost (23 eyes) monotherapy were included. CCT assessments were performed at baseline and 1, 2, and 3 years after initiation of treatment.

Results: In the NTG group, the mean CCT showed a decreasing trend, and there was a significant difference in mean CCT at 1, 2, and 3 years compared with baseline (baseline, 538.16 ± 32.14; 1 year, 526.55 ± 37.30 μm [p = 0.00]; 2 years, 521.67 ± 36.79 μm [p = 0.00]; 3 years, 520.43 ± 36.88 μm [p = 0.00]). The reduction of CCT was confirmed by subgroup analysis. In the 0.005% latanoprost group, mean CCT was decreased at 1 year (p = 0.11), 2 years (p = 0.00), and 3 years (p = 0.02). In the 0.0015% tafluprost group and the 0.004% travoprost group, mean CCT was also significantly decreased at all years (p = 0.00). No statistical difference was observed between the NTG subgroups (p = 0.06).

Conclusions: Topical therapy with PGAs appeared to cause a significant decrease in CCT reduction in patients with NTG. A long-term follow-up study including more participants is needed.

키워드

Central corneal thickness; Low tension glaucoma; Prostaglandin analogue

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