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Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

Korean Journal of Internal Medicine 2020년 35권 3호 p.535 ~ 543
박태영 ( Park Tae-Young ) - Inje University Seoul Paik Hospital Department of Internal Medicine

오형철 ( Oh Hyoung-Chul ) - Chung-Ang University College of Medicine Department of Internal Medicine Division of Gastroenterology
 ( Fogel Evan L. ) - Indiana University School of Medicine Division of Gastroenterology and Hepatology
 ( Lehman Glen A. ) - Indiana University School of Medicine Division of Gastroenterology and Hepatology

Abstract


Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs (NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis.

키워드

Cholangiopancreatography, endoscopic retrograde; Pancreatitis; Anti-inflammatory agents, non-steroidal
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