잠시만 기다려 주세요. 로딩중입니다.

Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs

Korean Journal of Internal Medicine 2020년 35권 4호 p.793 ~ 796
박세윤 ( Park Se-Yoon ) - Soonchunhyang University Seoul Hospital Department of Internal Medicine

 ( Yun Soon-Gyu ) - Soonchunhyang University Seoul Hospital Department of Laboratory Medicine
신정원 ( Shin Jeong-Won ) - Soonchunhyang University Seoul Hospital Department of Laboratory Medicine
이보영 ( Lee Bo-Young ) - Soonchunhyang University Seoul Hospital Department of Internal Medicine
손효주 ( Son Hyo-Ju ) - Soonchunhyang University Seoul Hospital Department of Internal Medicine
이성재 ( Lee Seung-Jae ) - Soonchunhyang University Seoul Hospital Department of Internal Medicine
이은정 ( Lee Eun-Jung ) - Soonchunhyang University Seoul Hospital Department of Internal Medicine
김태형 ( Kim Tae-Hyong ) - Soonchunhyang University Seoul Hospital Department of Internal Medicine

Abstract


There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after remission of symptoms. We investigated the duration of SARS-CoV-2 RNA detection using real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 in nasopharyngeal/oropharyngeal swabs or sputum or saliva. Six patients were included in the final analysis. The median (range) duration of SARS-CoV-2 viral detection after hospitalization was 34 days (22 to 67). After resolution of symptoms/signs, SARS-CoV-2 RNA was detected for median (range) of 26 days (9 to 48). Among the six patients, one had persistent detection of SARS-CoV-2 RNA until day 67 of hospitalization, which was 30 days after symptom resolution. This case represents the longest duration of SARS-CoV-2 detection, and highlights the need for long-term follow up of COVID-19 patients despite resolution of symptoms to confirm SARS-CoV-2 clearance.

키워드

Severe acute respiratory syndrome coronavirus 2; COVID-19; Virus shedding
원문 및 링크아웃 정보
  
등재저널 정보