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A prospective randomized clinical study evaluating the efficacy and compliance of oral sulfate solution and 2-L ascorbic acid plus polyethylene glycol

Korean Journal of Internal Medicine 2020년 35권 4호 p.873 ~ 880
권기환 ( Kwon Ki-Hwan ) - Dongguk University Ilsan Hospital Department of Internal Medicine

이지애 ( Lee Ji-Ae ) - Korea University Guro Hospital Department of Internal Medicine
임윤정 ( Lim Yun-Jeong ) - Dongguk University Ilsan Hospital Department of Internal Medicine
이범재 ( Lee Beom-Jae ) - Korea University Guro Hospital Department of Internal Medicine
주문경 ( Joo Moon-Kyung ) - Korea University Guro Hospital Department of Internal Medicine
 ( Sim Yu-Ra ) - Korea University Guro Hospital Department of Internal Medicine
최원재 ( Choi Won-Jae ) - Korea University Guro Hospital Department of Internal Medicine
김태현 ( Kim Tae-Hyun ) - Korea University Guro Hospital Department of Internal Medicine
김지윤 ( Kim Ji-Yoon ) - Dongguk University Ilsan Hospital Department of Internal Medicine
 ( Cho Ei-Rie ) - Dongguk University Ilsan Hospital Department of Internal Medicine
진윤태 ( Jeen Yoon-Tae ) - Korea University Anam Hospital Department of Internal Medicine
박종재 ( Park Jong-Jae ) - Korea University Guro Hospital Department of Internal Medicine

Abstract


Background/Aims: Oral sulfate solution (OSS) is an emerging cleansing agent for bowel preparation. However, data comparing OSS to other conventional bowel preparations in Asian patients are limited. Therefore, the objective of this study was to compare the efficacy and tolerability of OSS to ascorbic acid plus polyethylene glycol (AA + PEG) in Asian patients.

Methods: This was a prospective, randomized, parallel, investigator-blind study performed in two university hospitals in Korea. Bowel preparation efficacy was evaluated using both the Ottawa Bowel Preparation Scale (OBPS) and Boston Bowel Preparation Scale (BBPS).

Results: Among 173 patients, 86 received OSS while 87 received AA + PEG for bowel preparation. Total OBPS score was 2.80 ± 2.48 in the OSS group and 4.49 ± 3.08 in the AA + PEG group, indicating significantly (p < 0.001) better efficacy with OSS. Total BBPS was higher in the OSS group (7.43 ± 1.49 vs. 6.51 ± 1.76, p < 0.001), indicating superior bowel preparation quality with OSS. Preparation-related adverse events were generally acceptable. Patients receiving OSS had more nausea (1.92 ± 0.94 vs. 1.54 ± 0.76, p = 0.004) and abdominal cramping (1.45 ± 0.78 vs. 1.17 ± 0.51, p = 0.006) than those receiving AA + PEG. However, overall satisfaction and taste were similar between the two groups.

Conclusions: OSS had a non-inferior bowel cleansing efficacy than AA + PEG regardless of colon segment.

키워드

Ascorbic acid; Bowel preparation; Colonoscopy; Oral sulfate solution; Polyethylene glycols
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