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The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers

Korean Journal of Internal Medicine 2020년 35권 4호 p.929 ~ 935
유승수 ( Yoo Seung-Soo ) - Kyungpook National University Hospital Department of Internal Medicine

강효경 ( Kang Hyo-Gyoung ) - Kyungpook National University School of Medicine Department of Biochemistry and Cell Biology
최진은 ( Choi Jin-Eun ) - Kyungpook National University School of Medicine Department of Biochemistry and Cell Biology
홍미정 ( Hong Mi-Jeong ) - Kyungpook National University School of Medicine Department of Biochemistry and Cell Biology
 ( Do Sook-Kyung ) - Kyungpook National University School of Medicine Department of Biochemistry and Cell Biology
 ( Lee Jang-Hyuck ) - Kyungpook National University School of Medicine Department of Biochemistry and Cell Biology
이원기 ( Lee Won-Kee ) - Kyungpook National University School of Medicine Medical Research Collabration Center
이신엽 ( Lee Shin-Yup ) - Kyungpook National University Hospital Department of Internal Medicine
이재희 ( Lee Jae-Hee ) - Kyungpook National University Hospital Department of Internal Medicine
차승익 ( Cha Seung-Ick ) - Kyungpook National University Hospital Department of Internal Medicine
김창호 ( Kim Chang-Ho ) - Kyungpook National University Hospital Department of Internal Medicine
이응배 ( Lee Eung-Bae ) - Kyungpook National University School of Medicine Department of Thoracic Surgery
박재용 ( Park Jae-Yong ) - Kyungpook National University School of Medicine Department of Biochemistry and Cell Biology

Abstract


Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers.

Methods: This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay.

Results: Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma.

Conclusions: These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.

키워드

Lung neoplasms; Smokers; Non-smokers; Risk; Polymorphism
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