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Clinical characteristics of coronavirus disease 2019 patients with diarrhea in Daegu

Korean Journal of Internal Medicine 2020년 35권 6호 p.1261 ~ 1269
강민규, 김경옥, 김민철, 조준현, 김성범, 박정길, 김국현, 이시형, 장병익, 김태년,
소속 상세정보
강민규 ( Kang Min-Kyu ) - Yeungnam University College of Medicine Department of Internal Medicine
김경옥 ( Kim Kyeong-Ok ) - Yeungnam University College of Medicine Department of Internal Medicine
김민철 ( Kim Min-Cheol ) - Yeungnam University College of Medicine Department of Internal Medicine
조준현 ( Cho Joon-Hyun ) - Yeungnam University College of Medicine Department of Internal Medicine
김성범 ( Kim Sung-Bum ) - Yeungnam University College of Medicine Department of Internal Medicine
박정길 ( Park Jung-Gil ) - Yeungnam University College of Medicine Department of Internal Medicine
김국현 ( Kim Kook-Hyun ) - Yeungnam University College of Medicine Department of Internal Medicine
이시형 ( Lee See-Hyung ) - Yeungnam University College of Medicine Department of Internal Medicine
장병익 ( Jang Byung-Ik ) - Yeungnam University College of Medicine Department of Internal Medicine
김태년 ( Kim Tae-Nyeun ) - Yeungnam University College of Medicine Department of Internal Medicine

Abstract


Background/Aims: Coronavirus disease 2019 (COVID-19) can reportedly cause gastrointestinal symptoms. Therefore, we investigated the clinical characteristics of COVID-19 patients with diarrhea.

Methods: We included 118 COVID-19 patients admitted to a single hospital from February 20 to March 31, 2020. Medical records with clinical characteristics, laboratory data, treatment course, and clinical outcomes were compared based on the presence or absence of diarrhea. Prognostic factors for disease severity and mortality in COVID-19 were also assessed.

Results: Among patients, 54 (45.8%) had diarrhea, whereas seven (5.9%) had only diarrhea. The median age of patients with diarrhea was 59 years (44 to 64), and 22 (40.7%) were male. Systemic steroid use, intensive care unit admission, septic shock, and acute respiratory distress syndrome were less frequent in the diarrhea group than in the non-diarrhea group. No significant differences were observed in total hospital stay and mortality between groups. On multivariate analysis, age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.01 to 1.12; p = 0.044), diabetes (OR, 3.00; 95% CI, 1.25 to 20.47; p = 0.042), and dyspnea (OR, 41.19; 95% CI, 6.60 to 823.16; p < 0.001) were independent risk factors for septic shock. On Cox regression analysis, diabetes (hazard ratio [HR], 4.82; 95% CI, 0.89 to 26.03; p = 0.043) and chronic obstructive pulmonary disease (HR, 16.58; 95% CI, 3.10 to 88.70; p = 0.044) were risk factors for mortality.

Conclusions: Diarrhea was present in 45.8% of patients and was a common symptom of COVID-19. Although patients with diarrhea showed less severe clinical features, diarrhea was not associated with disease severity or mortality.

키워드

COVID-19; Diarrhea; Shock, septic; Mortality

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