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Renal effects of uric acid: hyperuricemia and hypouricemia

Korean Journal of Internal Medicine 2020년 35권 6호 p.1291 ~ 1304
박중환, 조용일, 이종호,
소속 상세정보
박중환 ( Park Jung-Hwan ) - Konkuk University School of Medicine Department of Internal Medicine
조용일 ( Jo Yong-Il ) - Konkuk University School of Medicine Department of Internal Medicine
이종호 ( Lee Jong-Ho ) - Konkuk University School of Medicine Department of Internal Medicine

Abstract


The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function. Recent observational studies of healthy populations and patients with CKD have reported that uric acid (UA) has an independent role in the development or progression of CKD. Experimental studies have shown several potential mechanisms by which hyperuricemia may cause or promote CKD. However, other reports have indicated an association between hypouricemia and CKD. This opposing effect is hypothesized to occur because UA is a major antioxidant in human plasma and is associated with oxidative stress. In this article, we discuss the potential association between UA imbalance and CKD and how they can be treated.

키워드

Uric acid; Hyperuricemia; Hypouricemia; Kidney

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