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The clinical impact of gut microbiota in chronic kidney disease

Korean Journal of Internal Medicine 2020년 35권 6호 p.1305 ~ 1316
김소미, 송일한,
소속 상세정보
김소미 ( Kim So-Mi ) - Dankook University Hospital Department of Internal Medicine
송일한 ( Song Il-Han ) - Dankook University Hospital Department of Internal Medicine

Abstract


Gut microorganisms play critical roles in both maintaining host homeostasis and the development of diverse diseases. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly seen in patients with chronic kidney disease (CKD). CKD itself contributes to a disruption of the symbiotic relationship between the gut microbiota and the host, while the resulting gut dysbiosis may play a part in stage progression of CKD. This bidirectional relationship supports the concept that the gut microbiota is considered a novel focus for the pathogenesis and management of CKD. This article examines the interaction between the gut microbiota and the kidney, the mutual effects of dysbiosis and CKD, and possible treatment options to restore gut eubiosis, and reduce CKD progression and its related complications.

키워드

Renal insufficiency, chronic; Gastrointestinal microbiome; Dysbiosis; Uremic toxins

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