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Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean

Korean Journal of Internal Medicine 2020년 35권 6호 p.1354 ~ 1363
최윤진, 이동호, 한경도,
소속 상세정보
최윤진 ( Choi Yoon-Jin ) - Seoul National University Bundang Hospital Department of Internal Medicine
이동호 ( Lee Dong-Ho ) - Seoul National University Bundang Hospital Department of Internal Medicine
한경도 ( Han Kyung-Do ) - Catholic University College of Medicine Department of Biostatistics

Abstract


Background/Aims: In Korea, the incidence of colorectal cancer (CRC) and non-alcoholic fatty liver disease (NAFLD) has increased due to a westernized lifestyle. This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC.

Methods: Data from the National Health Insurance Corporation 2009 to 2012 were analyzed. NAFLD disease was defined as a fatty liver index > 60 in the absence of alcohol consumption of ≥ 30 g/day.

Results: NAFLD was identified in 2,543,649 (11.8%) of 21,592,374 participants. CRC was identified in 19,785 (0.8%) of participants with NAFLD (fatty liver index ≥ 60) and in 80,871 (0.6%) participants without NAFLD (fatty liver index < 30). Multivariate logistic regression analysis demonstrated an independent association between NAFLD and CRC after adjusting for other confounders (hazard ratio, 1.13; odds ratio, 1.12 to 1.15). In subgroup analyses, fatty liver index ≥ 60 was associated with CRC regardless of body mass index, but the association was more prominent in persons with a normal index. NAFLD, in the absence of diabetes, hypertension, or dyslipidemia, was more highly associated with CRC than when one or more of these conditions are present.

Conclusions: CRC should be considered as a possibility in patients with fatty liver index ≥ 60, even in the absence of obesity or other metabolic syndromes.

키워드

Colorectal neoplasms; Non-alcoholic fatty liver disease; Metabolic syndrome

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