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Anxiety, depression, and stress in Korean patients with chronic urticaria

Korean Journal of Internal Medicine 2020년 35권 6호 p.1507 ~ 1516
최길순, 남영희, 박찬선, 김미영, 조은정, 박혜경, 김희규,
소속 상세정보
최길순 ( Choi Gil-Soon ) - Kosin University College of Medicine Department of Internal Medicine
남영희 ( Nam Young-Hee ) - Dong-A University College of Medicine Department of Internal Medicine
박찬선 ( Park Chan-Sun ) - Inje University Haeundae Paik Hospital Department of Internal Medicine
김미영 ( Kim Mi-Yeong ) - Inje University Busan Paik Hospital Department of Internal Medicine
조은정 ( Jo Eun-Jung ) - Pusan National University School of Medicine Department of Internal Medicine
박혜경 ( Park Hye-Kyung ) - Pusan National University School of Medicine Department of Internal Medicine
김희규 ( Kim Hee-Kyoo ) - Kosin University College of Medicine Department of Internal Medicine

Abstract


Background/Aims: Emotional distress is thought to cause or maintain chronic urticaria (CU). We aimed to investigate the presence of anxiety, depression, and stress in Korean adult CU patients and to explore their potential impact on treatment.

Methods: We enrolled 79 CU patients and a disease control group comprising 39 persistent asthma patients. The Hospital Anxiety and Depression Scale (HADS) was used to evaluate depression and anxiety. Stress and quality of life (QoL) were assessed by Stress Response Inventory and CU-QoL questionnaires. The sociodemographic and clinical data such as urticaria activity score (UAS-15, UAS-6) were obtained.

Results: The prevalence of depression and anxiety based on the HADS were 48.1% and 38.0%. Although the prevalence of anxiety didn’t differ between the CU and asthma patients, depression was significantly more prevalent in the CU patients (48.1% vs. 28.2%). Stress tended to be lower in CU patients. Anxiety, depression, and stress exhibited negative correlations with QoL. Anxiety showed significant correlation with UAS-6 and pruritus-visual analog scale (VAS; r = 0.256, r = 0.272, p < 0.05, respectively); depression correlated with sleep difficulty-VAS (r = 0.261, p < 0.05). Stress was associated with UAS-15, UAS-6, pruritus-VAS, and sleep difficulty-VAS (r = 0.251, r = 0.317, r = 0.302, r = 0.258, p < 0.05, respectively).

Conclusions: The current study first presented that Korean CU patients frequently have anxiety and depression, which affect their QoL and demonstrated that anxiety, depression, and stress had different effects on sleep difficulty, pruritus, and urticaria severity in Korean CU patients.

키워드

Chronic urticaria; Psychiatric disorders; Depression; Anxiety; Stress

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