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New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng

Journal of Ginseng Research 2020년 44권 3호 p.405 ~ 412
 ( Shang Jia-Huan ) - Chinese Academy of Sciences Kunming Institute of Botany

 ( Sun Wen-Jie ) - Chinese Academy of Sciences Kunming Institute of Botany
 ( Zhu Hong-Tao ) - Chinese Academy of Sciences Kunming Institute of Botany
 ( Wang Dong ) - Chinese Academy of Sciences Kunming Institute of Botany
 ( Yang Chong-Ren ) - Chinese Academy of Sciences Kunming Institute of Botany
 ( Zhang Ying-Jun ) - Chinese Academy of Sciences Kunming Institute of Botany

Abstract


Thirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely, 20(S)-dammar-25-ene-24(S)-hydroperoxyl-3β,6α,12β,20-tetrol (1), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-6α,12β,20-triol (2), 20(S)-dammar-12-oxo-23-ene-25-hydroperoxyl-3β,6α,20-triol (3), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-12β,20-diol (4), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid (5), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid methyl ester (6), and 6α-hydroxy-22,23,24,25,26,27-hexanordammar-3,12,20-trione (7), are new compounds. In addition, 12 known ones (12?16 and 19?25) were reported in Sanqi for the first time. The new Compound 1 showed comparable antiinflammatory activity on inhibition of NO production to the positive control, whereas the known compounds 9, 12, 13, and 16 displayed moderate cytotoxicities against five human cancer cell lines. The results will provide scientific basis for understanding the chemical constituents of Sanqi rot roots and new candidates for searching antiinflammatory and antitumor agents.

키워드

20,24-epoxylated; Dammarane-type triterpenes; Hydroperoxylated; Panax notoginseng; Inhibition of NO production
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