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Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B?irradiated hairless mice

Journal of Ginseng Research 2020년 44권 3호 p.496 ~ 505
 ( Saba Evelyn ) - Kyungpook National University Laboratory of Physiology and Cell Signalling

김승형 ( Kim Seung-Hyung ) - Daejeon University Institute of Traditional Medicine and Bioscience
 ( Lee Yuan-Yee ) - Kyungpook National University Laboratory of Physiology and Cell Signalling
박재규 ( Park Chae-Kyu ) - KGC R&D Headquarters
오재욱 ( Oh Jae-Wook ) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
김태환 ( Kim Tae-Hwan ) - Kyungpook National University Laboratory of Physiology and Cell Signalling
김현경 ( Kim Hyun-Kyoung ) - Seowon University Department of Food Science and Engineering
노성수 ( Roh Seong-Soo ) - Daegu Haany University College of Korean Medicine
이만휘 ( Rhee Man-Hee ) - Kyungpook National University Laboratory of Physiology and Cell Signalling

Abstract


Background: Panax ginseng is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means “cure for all”. Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation.

Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extract in vitro and HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG in vivo. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin.

Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In the in vivo experiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone.

Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.

키워드

Antiaging; Human trials; Korean Red Ginseng extract; Melanogenesis; Wrinkles
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