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Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice

Journal of Ginseng Research 2020년 44권 3호 p.519 ~ 526
이정근 ( Lee Jeong-Geun ) - Sejong University College of Life Sciences Department of Integrative Bioscience and Biotechnology

박준우 ( Park Joon-Woo ) - Sejong University College of Life Sciences Department of Integrative Bioscience and Biotechnology
 ( Lee Yong-Yook ) - Korea Ginseng Corporation Korea Ginseng Research Institute
이영주 ( Lee Young-Joo ) - Sejong University College of Life Sciences Department of Integrative Bioscience and Biotechnology

Abstract


Background: Bisphenol A (BPA), known as an endocrine disruptor, is widely used in the world. BPA is reported to cause inflammation-related diseases. Korean Red Ginseng (KRG) has been used safely in human for a long time for the treatment of diverse diseases. KRG has been reported of its mitigating effect on menopausal symptoms and suppress adipose inflammation. Here, we investigate the protective effect of orally administered KRG on the impacts of BPA in the liver and uterus of menopausal mice model.

Methods: The transcriptome analysis for the effects of BPA on mice liver was evaluated by Gene Expression Omnibus (GEO) database?based data (GSE26728). In vivo assay to evaluate the protective effect of KRG on BPA impact in ovariectomized (OVX) mice were designed and analyzed by RNA sequencing.

Results: We first demonstrated that BPA induced 12 kinds of gene set in the liver of normal mice. The administration of BPA and KRG did not change body, liver, and uterine weight in OVX mice. KRG downregulated BPA-induced inflammatory response and chemotaxis-related gene expression. Several gene set enrichment analysis (GSEA)?derived inflammatory response genes increased by BPA were inhibited by KRG in OVX mice.

Conclusion: Our data suggest that BPA has commonly influenced inflammatory response effects on both normal and OVX mice. KRG protects against BPA impact of inflammatory response and chemotaxis in OVX mouse models. Our comparative analysis will provide new insight into the efficacy of KRG on endocrine disrupting chemicals and OVX mouse.

키워드

Bisphenol A; Korean Red Ginseng; Transcriptome analysis
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