잠시만 기다려 주세요. 로딩중입니다.

Bone remodeling effects of Korean Red Ginseng extracts for dental implant applications

Journal of Ginseng Research 2020년 44권 6호 p.823 ~ 832
강명훈, 이숙정, 이민호,
소속 상세정보
강명훈 ( Kang Myong-Hun ) - Chonbuk National University School of Dentistry Department of Dental Biomaterials
이숙정 ( Lee Sook-Jeong ) - Chonbuk National University Department of Bioactive Material Sciences
이민호 ( Lee Min-Ho ) - Chonbuk National University School of Dentistry Department of Dental Biomaterials

Abstract


Background: The formation of a nanotube layer on a titanium nanotube (N-Ti) plate facilitates an active reaction between bone cells and the material surface via efficient delivery of the surface materials of the dental implant into the tissues. Studies have reported that Korean Red Ginseng extracts (KRGEs) are involved in a variety of pharmacological activities: we investigated whether implantation with a KRGE-loaded N-Ti miniimplant affects osteogenesis and osseointegration.

Methods: KRGE-loaded nanotubes were constructed by fabrication on pure Ti via anodization, and MC3T3-E1 cells were cultured on the N-Ti. N-Ti implants were subsequently placed on a rat's edentulous mandibular site. New bone formation and bone mineral density were measured to analyze osteogenesis and osseointegration.

Results: KRGE-loaded N-Ti significantly increased the proliferation and differentiation of MC3T3-E1 cells compared with cells on pure Ti without any KRGE loading. After 1?4 weeks, the periimplant tissue in the edentulous mandibular of the healed rat showed a remarkable increase in new bone formation and bone mineral density. In addition, high levels of the bone morphogenesis protein-2 and bone morphogenesis protein-7, besides collagen, were expressed in the periimplant tissues.

Conclusion: Our findings suggest that KRGE-induced osteogenesis and osseointegration around the miniimplant may facilitate the clinical application of dental implants.

키워드

Korean Red Ginseng extracts; Osseointegration; Osteogenesis; Titanium miniimplant; Titanium nanotubes

원문 및 링크아웃 정보

등재저널 정보