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Effects of antibiotics at sub-minimal inhibitory concentrations on the morphology of Streptococcus mutans and Lactobacillus acidophilus

구강생물학연구 2020년 44권 1호 p.1 ~ 7
 ( Kwon Ye-Won ) - Gangneung-Wonju National University College of Dentistry Department of Microbiology and Immunology

이시영 ( Lee Si-Young ) - Gangneung-Wonju National University College of Dentistry Department of Microbiology and Immunology

Abstract


Sub-minimal inhibitory concentrations (sub-MICs) of antibiotics may have significant impact on the morphology and biochemical characteristics of target bacteria. This study aimed to examine the morphological changes to sub-MICs of antibiotics observed in bacterial cells from Gram-positive oral species, Streptococcus mutans and Lactobacillus acidophilus . The MICs for both amoxicillin and doxycycline were determined by broth dilution method. Individual cells of S . mutans increased in length after incubation with sub-MIC of amoxicillin, whereas its chain length increased in response to a sub-MIC of doxycycline. The lengths of individual bacterial cells of L . acidophilus decreased after incubation with sub-MICs of either amoxicillin or doxycycline. These results of suggest that subMICs of amoxicillin and doxycycline induce morphological changes in both S . mutans and L . acidophilus . Further studies are required to determine the significance of these findings for host?pathogen interactions and development of dental diseases.

키워드

Lactobacillus acidophilus; Morphology; Streptococcus mutans; Sub-minimal inhibitory concentration
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